What Can Peptides Do for Your Skin?

Peptides – What Can They Do for Your Skin?

Aging is a fact of life, we all age and there’s nothing we can do about it. We all know there’s no such thing as a ‘fountain of youth’. But wouldn’t it be great if we had the ability to age more gracefully? You know, with less wrinkles, fine lines and sagging skin? This where peptides come in – and no matter what your age, they can be a game changer for your skin’s appearance.

Peptides have been around for almost a century, having first been identified in Germany in 1902. Peptide therapeutics have played a notable role in medical practice since the advent of insulin therapy in the 1920s. New peptides are being discovered and developed all the time, with therapeutic potential to treat a wide range of medical conditions.

Many peptides are developed naturally in our bodies, but unfortunately they become depleted as we age. To help minimize and even reduce the effects of aging, it’s important to start a skin care regimen that includes peptides. But which peptides are actually the most beneficial for skin care?

The following really stand out as peptides that can help produce visible results and improve the appearance of your skin.

GHK-Cu (Copper Tri-Peptide-1)

Copper peptides are small protein fragments that have a high affinity for copper ions critical to normal body function. GHK-Cu is a naturally occurring human tri-peptide that plays an important role in skin biology, and is highly effective in skin care products as a reparative and anti-aging ingredient. GHK-Cu was first discovered in 1973 by biochemist Dr. Loren Pickart.

The skin’s ability to withstand damage and repair itself is highest in children and young individuals because of well-functioning repair and protective mechanisms. However, with age, the skin’s ability to repair damage declines. GHK content is highest in the plasma of young, healthy individuals. The levels of GHK decrease as you age – by age 60 we have less than half the amount we had at age 20.

Controlled studies of GHK-Cu on aged skin have demonstrated that it tightens skin, improves elasticity and firmness, and reduces fine lines, wrinkles, photo-damage and hyper-pigmentation. GHK-Cu has been shown to increase collagen in photo-aged skin, performing better than both Vitamin C and retinoic acid. It also acts as an antioxidant and promotes production of
glycosaminoglycans (such as hyaluronic acid). One 12-week study reported significant improvement of skin laxity, clarity and appearance, reduction of fine lines and depth of wrinkles along with increased skin density and thickness. Copper peptide GHK-Cu has been found to be both non-toxic and non-irritating.

Benefits of GHK-Cu:

• Tighten loose skin and reverse thinning of aged skin

• Repair protective skin barrier proteins

• Improve skin firmness, elasticity, and clarity

• Reduce fine lines, depth of wrinkles, and improve structure of aged skin

• Smooth rough skin

• Reduce photo-damage, mottled hyper-pigmentation, skin spots and lesions

• Improve overall skin appearance

• Protect skin cells from UV radiation

• Reduce inflammation and free radical damage

Adding GHK-Cu to your skin care regimen can help repair sun damage and the effects of aging to restore a more youthful looking complexion.

Palmitoyl Tripeptide-5

A synthetic peptide that is believed to play a role in the appearance of skin firmness, Palmitoyl Tripeptide-5 is made up of chains of amino acids linked by peptide bonds. It can penetrate the skin’s surface layer (epidermis) and enter deep into the dermis layer, where may help to stimulate collagen production and healthy tissue growth. 

Most peptides are made up of chains of amino acids, which are directly involved in the creation of proteins in the body. Studies into the function of Palmitoyl Tripeptide-5 suggest that its chains of amino acids communicate with the skin’s collagen production systems and boost its production, which is a significant factor in achieving smooth, wrinkle-free skin. 

One of the most effective ways to choose anti-aging products is to understand how the ingredients contained within them will affect your skin. Palmitoyl Tripeptide-5 is a man-made synthetic that is designed to communicate with the skin’s cells to keep them functioning optimally. Cell communication is a relatively new concept when it comes to skincare and anti-aging. For centuries, skincare revolved around applying nourishing oils and ingredients to the surface of the skin. But recent studies have shown that ingredients like Palmitoyl Tripeptide-5 in skin care products may keep skin healthier and younger-looking longer by improving collagen production and supporting healthy skin cell function.

It is also believed that Palmitoyl Tripeptide-5 may interact synergistically with hyaluronic acid and elastin production systems. The combined effect is increased water content in skin cells, improved appearance of fine lines and wrinkles, and a thickening of the skin. Additionally, studies have suggested that it helps support the healthy functioning of skin cells by improving toxin removal. 

Palmitoyl Pentapeptide-4

This peptide consists of five amino acids (lysinethreonine, threonine, lysine, and serine) linked to palmitoyl for better oil solubility and skin penetration. It is believed to act as a messenger peptide that regulates cell activities, such as activating the target cell to synthesize extracellular collagen and hyaluronic acid.

Palmitoyl Pentapeptide-4 has been shown to have similar results to Retinol but without the skin irritation. Sometimes it’s also called collagen pentapeptide, as it’s a sub-fragment of type I collagen – the substance that gives skin its structure and firmness. The effectiveness of Palmitoyl Pentapeptide-4 is demonstrated as a positive impact on reducing fine lines and wrinkles. It creates a response in skin cells that triggers collagen stimulation and healthy production of elastin fibroblasts. It is a small enough molecule to easily penetrate the skin surface, creating an interactive network with skin cells that are prompted to start repairing the skin.

In independent double blind studies, Palmitoyl Pentapeptide-4 demonstrated significant improvement in skin roughness, wrinkle depth and volume, as well as an increase and improvement in elastin density and collagen. (SK Schagen, 2017). Retrieved from https://www.mdpi.com/.

Promise Pharmacy offers a variety of quality prescription strength, custom-compounded anti-aging skin care products containing these peptides. Please visit our website to learn more!

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